Predictors of walking capacity in peripheral arterial disease patients

OBJECTIVE: To estimate walking capacity in intermittent claudication patients through a prediction model based on clinical characteristics and the walking impairment questionnaire. METHODS: The sample included 133 intermittent claudication patients of both genders aged between 30 and 80 years. Data regarding clinical characteristics, the walking impairment questionnaire and treadmill walking test performance were obtained. Multiple regression modeling was conducted to predict claudication onset distance and total walking distance using clinical characteristics (age, height, mass, body mass index, ankle brachial index lower, gender, history of smoking and co-morbid conditions) and walking impairment questionnaire responses. Comparisons of claudication onset distance and total walking distance measured during treadmill tests and estimated by a regression equation were performed using paired t-tests. RESULTS: Co-morbid conditions (diabetes and coronary artery disease) and questions related to difficulty in walking short distances (walking indoors - such as around your house and walking 5 blocks) and at low speed (walking 1 block at average speed - usual pace) resulted in the development of new prediction models high significant for claudication onset distance and total walking distance (p0.05) were observed. CONCLUSION: The current study demonstrated that walking capacity can be adequately estimated based on co-morbid conditions and responses to the walking impairment questionnaire

Modernización y sindicatos

La presente obra intenta contribuir a la comprensión de los impactos, contradicciones y desafíos que plantea a los sindicatos y a los trabajadores la reestructuración productiva y tecnológica. Los diversos ensayos que la componen no sólo formulan diagnósticos y examinan casos, también realizan un escarceo en torno a las alternativas sindicales, ante la necesidad de elevar la productividad y la inevitable formulación de una nueva Ley Federal del Trabajo, pues la actual es obsoleta, ante el derrumbe de los basamentos en que se sustentaba

Trigonometric Parallaxes of Massive Star Forming Regions: III. G59.7+0.1 and W 51 IRS2

We report trigonometric parallaxes for G59.7+0.1 and W 51 IRS2, corresponding to distances of 2.16^{+0.10}_{-0.09} kpc and 5.1^{+2.9}_{-1.4} kpc, respectively. The distance to G59.7+0.1 is smaller than its near kinematic distance and places it between the Carina-Sagittarius and Perseus spiral arms, probably in the Local (Orion) spur. The distance to W 51 IRS2, while subject to significant uncertainty, is close to its kinematic distance and places it near the tangent point of the Carina-Sagittarius arm. It also agrees well with a recent estimate based on O-type star spectro/photometry. Combining the distances and proper motions with observed radial velocities gives the full space motions of the star forming regions. We find modest deviations of 5 to 10 km/s from circular Galactic orbits for these sources, both counter to Galactic rotation and toward the Galactic center.Comment: 16 pages, 6 figures; to appear in the Astrophysical Journa

A neural network modeling of the immunogenic activity of tumor derived peptides

Los péptidos derivados de proteínas específicas de tumores pueden activar el sistema inmune contra las células tumorales. Para promover la respuesta inmune, los péptidos deben primero unirse a las moléculas del complejo principal de histocompatibilidad. Aunque algunas posiciones de la secuencia del péptido inmunogénico necesitan aminoácidos "ancla" específicos, el resto de los residuos también influye en la afinidad de la unión. Modelamos el efecto de la sustitución de aminoácidos, en la afinidad de unión de los péptidos utilizando una red neural artificial. La red predice correctamente la especificidad de las posiciones de anclaje, pero también sugiere que los aminoácidos con propiedades similares pueden ser incluidos en la secuencia de los péptidos con alta probabilidad de tener alta afinidad de unión.Peptides derived from tumor-specific proteins can activate the immune system against tumor cells. To promote the immune response, peptides must first bind to the major histocompatibility complex molecules. Although some positions of the immunogenic peptide sequence need specific “anchor” amino acids, the rest of the residues also influence the binding affinity. We modeled the effect of amino acids substitution on the binding affinity of peptides using an artificial neural network. The network correctly predicts the specificity of the anchor positions but also suggests that amino acids with similar properties can be included in the sequence of the peptides with high probability of having high binding affinity

A study about the universals in Ideas I

The problem of universals remains a philosophical theme not only in ontology but also in epistemology. In Husserl, there are particular universals, the noematic ‘X’, the identical, and universals stricto sensu, atemporal universal names. In this paper, I present the theme as it is analyzed by Husserl in Ideas I. In the first section, I describe the trajectory to the universals highlighting the parallelism between noese and noema. In the second section, I draw the reflection of this problem on the philosophy of language which is also affected by the noeticnoematic correspondence. In the third and last section, I show how the investigation about the universals moves in the noematic sphere, and conclude defending the possibility of reaching the universal strict sense departing from the noematic ‘X’